BENDAMUSTINE IS A SAFE AND EFFECTIVE LYMPHODEPLETION AGENT FOR AXICABTAGENE CILOLEUCEL IN PATIENTS WITH REFRACTORY OR RELAPSED LARGE B-CELL LYMPHOMA

Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma

Background Fludarabine in combination with cyclophosphamide (FC) is the standard lymphodepletion regimen for CAR T-cell therapy (CAR T).A national fludarabine shortage in 2022 necessitated the exploration of alternative regimens with many centers employing single-agent bendamustine as lymphodepletion despite a lack of clinical safety and efficacy d

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The Africa of 2022: Crisscrossing Crises

The year 2022 aveline by modway marked the 20th anniversary of the African Union (AU)).The AU marked a realisation that the Organisation of African Unity (OAU) established in 1963 had fulfilled its mandate of ridding the continent of overt colonial rule and a new platform was needed to drive Africa towards motiv thrill pink yellow full prosperity.C

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