Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9

Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9

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Long non-coding RNAs (lncRNAs) have been identified as influential indicators in variety of malignancies.Among which, LncRNA RUNDC3A-AS1 is reported to upregulate in thyroid cancer.However, the expression pattern and the pathological function of lncRNA RUNDC3A-AS1 in thyroid cancer is unclear.In this study, we examined the expression levels of lncRNA RUNDC3A-AS1 in the thyroid cancer tissues and cell lines via RT-qPCR analysis.The effects of RUNDC3A-AS1 on thyroid the beast sullivan supply cancer cell metastasis were detected by transwell chamber assay, scratch assay in vitro and lung metastasis model in vivo.

The results indicated that RUNDC3A-AS1 was highly expressed in the thyroid cancer tissues and cell emtek freestone finger pull lines.Functionally, knockdown of RUNDC3A-AS1 could repress the migration and invasion of thyroid cancer cells in vitro, and inhibit thyroid cancer metastasis to lung in vivo.Mechanistically, RUNDC3A-AS1 served as an inhibitor of miR-182-5p in tumor tissues and cell lines.RUNDC3A-AS1 inhibited the expression of miR-182-5p to increase the expression level of ADAM9, thus further aggravating the malignancy of thyroid cancer.Therefore, the RUNDC3A-AS1/miR-182-5p/ADAM9 axis may be a potential therapeutic target for the treatment of thyroid cancer metastasis.